The female mad scientist, loosely considered the protagonist;
An incredibly brilliant, but snarky, AI assistant, who later gains hard-light projection abilities and even later still gains a body (a la the series Andromeda and the titular ship);
The male mad scientist, an initial new recruit (but unlike Narbonic, he's mad from the getgo);
A bimbo female assistant who sleeps with literally everyone in the main cast (which does mean that the entire crew ends up polyamorous, in large part thanks to her), who eventually gains alternate selves (portrayed respectfully since I am plural and wish to show a good portrayal of a form of plural), one an "evil" version that is into BDSM, is smarter, more grounded, and yet, is also incredibly violent, and a "good" version that is also smart, grounded, but annoyingly altruistic, and her normal self eventually works to become less of a klutz, and while not as smart, works to become a mediator between everyone;
An alien supergenius lifeform that's mostly a gigantic green brain, who is a rival to the female scientist and has claimed her lab as its own, leading to constant fighting and one-upping;
An evil mutant plant created by the alien, designed to consume and grow, hyper-intelligent on its own with big teeth that can eat anything and vines that are super-flexible (eventually in a spoiler revealed to be the author of the webcomic itself);
A less-evil mutant plant developed as a counterpart to the above made by the female mad scientist, with all of the traits of the above, who eventually becomes a renown author whose works are developed into films as well as a scientist, who is incredibly rude, crass, demeaning, insulting, etc., not to mention monstrous wearing a paper-thin disguise, and yet people still like the plant in spite of that.
It is a good idea, but alas, like most of mine, the extent of me making it will be me writing it down here.